The most trustworthy knowledge comes from systematic reviews where a whole body of work on a given topic is examined, using set ways of deciding what is relevant, how the quality of different studies should be judged and how the messages should be brought together. Looking at a whole body of work in this way means that there is less potential for the messages from research to be unduly affected by single studies. SCIE has worked with other organisations to develop a way of undertaking systematic reviews that takes account of a range of different types and quality of knowledge in social care.