This review on indicated prevention adds to the current knowledge and understanding of risk factors in the development of later drug problems and dependence, focusing on the mental health and behavioural problems that develop during childhood. Indicated prevention is a relatively new branch of drug prevention and can be seen as the third part of the ‘prevention chain’, after universal and selective prevention. Its aim is not necessarily to prevent drug use or initiation to it, but rather to prevent the development of dependence, diminish frequency of use and avert ‘dangerous’ patterns of substance use (e.g. moderate instead of binge-drinking).