This resource discuses exercise therapy as a treatment for mild or moderate depression. The report looks at research which indicates incidences of GP 'prescriptions' for exercise in the treatment of depression are low. The Mental Health Foundation is embarking on a campaign to promote exercise referral, the aim of which is to remove the main obstacle to the use of exercise therapy as a first-line treatment for mild or moderate depression in primary care – the failure of information to reach those who may be able to use it. Up and Running? marks the beginning of this campaign.