This report is part of the Innovation Series 2011 published by the Institute for Healthcare Improvement. This white paper outlines methods and opportunities to better coordinate care with people with multiple health and social needs, and reviews ways that organizations have allocated resources to better meet the range of needs in this population. There is special emphasis on the experience of care coordination with populations of people experiencing homelessness. Discussion includes measures used to track the impact of these efforts on health, costs, and experience of care. The role of strong partnerships between health care and community organizations is highlighted and innovative test ideas are included.