Targeted Youth Support (TYS) is an initiative aimed at vulnerable young people and involves ensuring that agencies work together to meet young people’s needs. This report was commissioned by the Department for Children, Schools and Families (DCSF) to explore what works for young people in relation to the outcomes prioritised by the TYS initiative. This systematic review was published by EPPI-Centre in 2008.Systematic reviews aim to find as much as possible of the research relevant to the particular research questions, and use explicit methods to identify what can reliably be said on the basis of these studies.